Two cases of chronic pancreatitis associated with anomalous pancreaticobiliary ductal union and SPINK1 mutation

• Published in: Clinical and experimental pediatrics pp. 227 - 230
• Main Authors: 노은삼, Earl Kim, 고홍, 유한욱, 이범희, 김구환(서울아산병원
• Format: Journal Article
• Language: English
• Published: 대한소아청소년과학회 01.05.2013
• Subjects: 소아과학
• ISSN: 2713-4148

Chronic pancreatitis is a progressive inflammatory disease resulting from repeated episodes of acute pancreatitis that impair exocrine function and eventually produce endocrine insufficiency. Some causes of chronic pancreatitis appear to be associated with alterations in the serine–protease inhibitor,Kazal type 1 (SPINK1 ), cationic trypsinogen (PRSS1 ), and cystic fibrosis–transmembrane conductance regulator (CFTR ) genes, or with structural disorders in the pancreaticobiliary ductal system, such as pancreatic divisum or anomalous pancreaticobiliary ductal union (APBDU). However, it is unusual to observe both genetic alteration and structural anomaly. Here, we report 2 cases with both APBDU and a mutation in the SPINK1 genes, and we discuss the implications of these findings in clinical practice. KCI Citation Count: 1