고빈도 전침자극이 류마토이드 관절염 통증 모델의 뇌 c-fos 발현에 미치는 영향

• Published in: Journal of acupuncture research pp. 211 - 220
• Main Authors: 차정호, 장소영, 이은용
• Format: Journal Article
• Language: Korean
• Published: 대한침구의학회 01.04.2007
• Subjects: 한의학
• ISSN: 2586-288X; 2586-2898

Objectives : This study was to investigate the effect of high frequency electroacupuncture at ST36 acupuncture point on the Complete Freund's Adjuvant (CFA) induced rat arthritis pain model. Methods : Arthritis was induced by intradermal injection of CFA into base of tail. Experimental groups were divided into 4 groups; Normal, Control and Jok-Samri (ST36) and Non-Acupuncture point (NA). Normal group, non-arthritic group, was injected with normal saline, and the others groups were injected CFA. ST36 group was treated by 120 ㎐ electroacupuncture at ST36 acupuncture point, and NA group was treated by 120 ㎐ electroacupuncture at non-acupuncture point. Each groups were evaluated by the change of c-fos positive neurons in periaqueductal gray (PAG) and hippocampus by using an image analyzer and a microscope. Results ; - In the PAG region, the number of fos-positive cells in the ST36 group (42.37±5.08) were significantly (p<0.05) decreased compared with the control group (64.56±6.35). - In the PAG region, the number of fos-positive cells in the NA group were meaninglessly decreased compared with the control group. - In the Cornu Ammonis(CA)1 region of hippocampus, the number of fos-positive cells in the ST36 group (7.00±1.08) and NA group (5.56±2.01) were significantly (p<0.05) decreased compared with the control group (13.81±1.24). - In the dentate gyrus region of hippocampus, the number of fos- positive cells in the ST36 group (10.75±0.98) and NA group (6.56±0.78) were significantly (p<0.05) decreased compared with the control group (26.45±1.82). Conclusions : It is expected that high frequency electroacupuncture can be used a treatment of arthritic pain. KCI Citation Count: 3