말 태반 가수분해 추출물의 Sprague-Dawley Rat를 이용한 단회 경구투여 독성시험

• Published in: Journal of acupuncture research pp. 105 - 110
• Main Authors: 여인호, 김이화, 이은용
• Format: Journal Article
• Language: Korean
• Published: 대한침구의학회 01.03.2014
• Subjects: 한의학
• ISSN: 2586-288X; 2586-2898

Objectives : The objective of this study is to analyze the single-dose toxicity of horse placenta hydrolysate extracts. Methods : Sprague-Dawley rats were chosen for the study. Doses of horse placenta hydrolysate extracts, 2,000 ㎎/㎏, 1,000 ㎎/㎏ and 500 ㎎/㎏, were administered to the experimental group, and the same doses of normal saline solution were administered to the control group. This study was conducted under the approval of the Institutional Animal Ethics Committee. Results : In all 4 groups, no deaths occurred, and the horse placenta hydrolysate extracts administered by oral was over 2,000 ㎎/㎏. No significant changes in the weight between the control group and the experimental group were observed.To check for abnormalities in organs and tissues, we used microscopy to examine representative histological sections of each specified organ, the results showed no significant differences in any organs or tissues. Conclusions : The above findings suggest that treatment with horse placenta hydrolysate extracts is relatively safe. Further studies on this subject should be conducted to yield more concrete evidence. KCI Citation Count: 0