항정신병제의 복용은 하지불안증후군의 위험 요소인가?

• Published in: Taehan Singyŏngkwa Hakhoe chi pp. 49 - 53
• Main Authors: 남현우, 조진환, 차정인, 정희연, 홍윤호
• Format: Journal Article
• Language: Korean
• Published: 대한신경과학회 01.02.2009
• Subjects: 신경과학
• ISSN: 1225-7044; 2288-985X

Background: Restless-legs syndrome (RLS) is known to be caused by dopaminergic hypofunction in the brain. We investigated whether antipsychotics that act as antidopaminergics increase the risk of RLS. Methods: We prospectively recruited 72 schizophrenic patients who had been medicated with antipsychotic drugs in a psychiatry clinic. We evaluated RLS diagnostic criteria and basic sleep habits using the Epworth Sleepiness Scale and Pittsburgh Sleep Quality Index by face-to-face interviews using a structured questionnaire. We also applied the Unified Parkinson’s Disease Rating Scale to evaluate extrapyramidal symptoms. Results: Three of the 72 patients (4.2%) met RLS criteria, which is similar to the previously reported RLS incidence among the general population in Korea. Conclusions: There is no evidence that antipsychotics increase the risk of RLS. We believe that the mild antidopaminergic effect of antipsychotics does not overwhelm their prominent antipsychotic effect. KCI Citation Count: 0