Intestinal anti-inflammatory effects of cinnamon extracts in a coculture model of intestinal epithelial Caco-2 cells and RAW264.7 macrophages
Cinnamon is the bark of Cinnamomum japonicum SIEB, which possesses anti-microbial, anti-tyrosinase, and antioxidant activities. However, studies on the intestinal health benefits of cinnamon are scarce. Therefore, we were aimed at assessing the potential anti-inflammatory action of cinnamon extracts...
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| Published in | Applied biological chemistry pp. 553 - 561 |
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| Main Authors | , |
| Format | Journal Article |
| Language | English |
| Published |
한국응용생명화학회
01.10.2017
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| Subjects | |
| Online Access | Get full text |
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| Summary: | Cinnamon is the bark of Cinnamomum japonicum SIEB, which possesses anti-microbial, anti-tyrosinase, and antioxidant activities. However, studies on the intestinal health benefits of cinnamon are scarce. Therefore, we were aimed at assessing the potential anti-inflammatory action of cinnamon extracts in a cellular model of intestinal inflammation. Cinnamon extracts were prepared using hot water extract and 70% ethanol extract.
Prior to inducing inflammation, co-cultured Caco-2 cells with RAW264.7 cells were treated with the cinnamon extracts. Lipopolysaccharide (LPS) was treated to induce inflammation in RAW264.7 cells. Compared to LPS-treated groups, the cells treated with cinnamon extracts maintained high transepithelial electrical resistance and decreased tight junction permeability, similar to that shown by control Caco-2 cells. In addition, cinnamon extracttreated cells showed decreased levels of inflammatory cytokines, namely nitrite (NO), PGE2, interleukin (IL)-6, IL-8, and TNF-a. These results show that cinnamon may serve as a probable agent for the development of functional supplements for maintenance of gastrointestinal health. KCI Citation Count: 7 |
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| ISSN: | 2468-0834 2468-0842 |