유도 AmpC β-lactamase를 생산하는 장내세균 혈액분리균에서의 extended-spectrum β-lactamase 생성균의 빈도

• Published in: Infection & chemotherapy pp. 280 - 284
• Main Authors: 정혜숙, 강철인, 정두련, 송재훈, 백경란, 고관수
• Format: Journal Article
• Language: Korean
• Published: 대한감염학회 01.10.2010
• Subjects: 내과학
• ISSN: 2093-2340; 2092-6448

Background: Among the inducible AmpC β-lactamase-producing members of the family Enterobacteriaceae such as Enterobacter spp., Citrobacter spp., Serratia spp.,and Morganella morganii (ECSM), the prevalence of ESBL-producing isolates are increasing. However, there have been only a limited number of studies that have investigated the prevalence for ESBL-production in blood isolates of these organisms. Materials and Methods: We performed a prospective observational study to evaluate the prevalence for ESBL production among ECSM blood isolates. All consecutive blood isolates in the Samsung Medical Center were included from Oct 2006 to Mar 2008. Antimicrobial susceptibility test was performed by broth microdilution method. ESBLs were confirmed by double-disk synergy test and ESBL phenotypes were determined by PCR. Results: The 124 isolates (94 Enterobacter spp., 18 Citrobacter spp., 8 Serratia spp. and 4 Morganella spp.) were investigated. Among 124 ESCM isolates, 30 isolates (24.2%) showed ESBL-producing activity. Derepressed or partially derepressed AmpC mutants and derepressed AmpC mutants with ESBL production accounted for 36.3% (45/124) and 16.9% (21/124), respectively. Of ESBL producers, the most prevalent ESBL was SHV-12 (5/24, 20.8%). Conclusions: The prevalence of ESBL-producing isolates is high in Enterobacter spp.,Serratia marcescens and Citrobacter spp. clinical isolates. It suggested that routine screening test for ESBLs among Enterobacteriacae blood isolates with inducible AmpC β-lactamase should be needed. KCI Citation Count: 2