만성 폐쇄성 폐질환 환자에서 기관지확장제의 사용에 따른 단독 폐용적 반응(isolated Volume response)과 GOLD 분류와의 관계

• Published in: Tuberculosis and respiratory diseases pp. 3 - 29
• Main Authors: 이상엽, 김제형, 신철, 유세화, 심재정, 이승현, 인광호, 강경호, 이승룡, 허규영, 정진용, 김세중, 이경주, 이은주, 정혜철
• Format: Journal Article
• Language: Korean
• Published: 대한결핵및호흡기학회 01.07.2005
• Subjects: 내과학
• ISSN: 1738-3536; 2005-6184

Background : Chronic obstructive lung disease is characterized by smoke-related, gradually progressive, fixed airflow obstructions. However, some studies suggested that a reversible bronchial obstruction is common in chronic obstructive lung disease. Such reversibility persists despite the continued treatment with aerosolized bronchodilators and it appears to be related to the diminution in symptoms. The isolated volume response to a bronchodilator is defined as a remarkable increase in the FVC in response to the administration of a bronchodilator whereas the FEV1 remains unchanged. This has been suggested in patients with severe emphysema. Therefore, the aim of this study was to determine the relationship between the response to a bronchodilator and the severity of an airflow obstruction in COPD patients using the GOLD classification. Methods : This study examined 124 patients with an airway obstruction. The patients underwent spirometry, and the severity of the airflow obstruction was classified by GOLD. The response groups were categorized by an improvement in the FVC or FEV1 > 12%, and each group was analyzed. Results : Most subjects were men with a mean age of 65.9±8.5 years. The mean smoking history was 41.26±20.1 pack years. The isolated volume response group had relatively low FEV1 and FVC values compared with the other groups. (p<0.001) Conclusion : In this study, an isolated volume response to a bronchodilator is a characteristic of a severe airway obstruction, which is observed in patient with a relatively poorer baseline lung function. (Tuberc Respir Dis 2005; 59: 23-29) KCI Citation Count: 0