Acaricidal Effects of Quinone and Its Congeners and Color Alteration ofDermatophagoides spp. with Quinone

• Published in: Journal of microbiology and biotechnology pp. 1394 - 1398
• Main Author: 이회선
• Format: Journal Article
• Language: English
• Published: 한국미생물·생명공학회 01.08.2007
• Subjects: 생물학
• ISSN: 1017-7825

Acaricidal activity of the active constituent derivedfrom Pyrus ussuriensis fruits against Dermatophagoidesfarinae and D. pteronysinus was examined and comparedwith that of the comercial benzyl benzoate. The LD50 valueof the ethyl acetate fraction obtained from the aqueous extractof P. ussuriensis fruits was 9.51 and 8.59g/cm3 againstD. farinae and D. pteronyssinus, respectively. The activeconstituent was identified as quinone by spectroscopic analyses.50 values with quinone and its congeners,the compound most toxic against D. farinae was quinone(1.19g/cm3), followed by quinaldine (1.46), benzyl benzoate(9.32), 4-quinolinol (86.55), quinine (89.16), and 2-quinolinol(91.13). Against D. pteronyssinus, these were quinone (1.02g/cm3), followed by quinaldine (1.29), benzyl benzoate (8.54),4-quinolinol (78.63), quinine (82.3), and 2-quinolinol (86.24).aqueous extracts can be mostly attributed to quinone. Quinonewas about 7.8 and 8.4 times more toxic than benzyl benzoateagainst D. farinae and D. pteronyssinus. Additionally, quinaldinewas about 6.4 and 6.6 times more toxic than benzyl benzoateagainst D. farinae and D. pteronyssinus, respectively. Furthermore,the skin color of the dust mites was changed from colorless-transparent to dark brown-black by the treatment of quinone.These results indicate that quinone can be very useful ashouse dust mites. KCI Citation Count: 5