네트워크 약리학적 방법론을 활용한 한의학 효능 연구 고찰

• Published in: 동의생리병리학회지, 30(6) pp. 419 - 425
• Main Authors: 백종민, 서한길, 권영규
• Format: Journal Article
• Language: Korean
• Published: 한의병리학회 01.12.2016
• Subjects: 한의학
• ISSN: 1738-7698; 2288-2529
• DOI: 10.15188/kjopp.2016.12.30.6.419

This study analyzed research methodologies based on network pharmacology to build a new system architecture optimized for Korean Medicine research. Results form studies using network pharmacology were collected and analyzed to evaluate the strength and weakness. Finally, an improved system architecture was proposed. Whether the predicted effects of drugs or herbs from network pharmacological analyses were in agreement with those from conventioanl knowledge of Korean Medicine was evaluated. These results were used to verify the applicability of research methodologies to the modern pharmacology and Korean Medicine respectively. Eighteen papers using TCMSP were collected and analyzed. The results suggest that the research methodology based on network pharmacology is appropriate only for the modern pharmacology but not for Korean Medicine. Information about compound-compound, herb-herb and drug-compound interactions need to be considered. We propose the modified system architecture with those information. KCI Citation Count: 0