CpG oligonucleotide and a-D-mannose conjugate for efficient delivery into macrophages

For improved intracellular uptake of CpG ODN into macrophages, we developed CpG ODN and mannose conjugate (CpG–Man conjugate) via simple conjugation of a-D-mannose to CpG ODN. CpG–Man conjugate showed greatly enhanced intracellular uptake by 2.1-fold into macrophages, compared to CpG ODN in a TLR-9...

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Bibliographic Details
Published inApplied biological chemistry pp. 759 - 763
Main Authors 정희선, Gyeonghui Yu, 목혜정
Format Journal Article
LanguageEnglish
Published 한국응용생명화학회 01.10.2016
Subjects
농학
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ISSN2468-0834
2468-0842

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Summary:For improved intracellular uptake of CpG ODN into macrophages, we developed CpG ODN and mannose conjugate (CpG–Man conjugate) via simple conjugation of a-D-mannose to CpG ODN. CpG–Man conjugate showed greatly enhanced intracellular uptake by 2.1-fold into macrophages, compared to CpG ODN in a TLR-9 receptorspecific manner. In addition, internalized CpG–Man conjugate successfully triggered TNF-a release in macrophages. Taken together, the CpG–Man conjugate can serve as the promising delivery systems of CpG ODN into immune cells as a candidate adjuvant. KCI Citation Count: 0
Bibliography:G704-000111.2016.59.5.009
ISSN:2468-0834
2468-0842