Secondary metabolites isolated from Castilleja rubra exert anti-inflammatory effects through NF-jB inactivation on lipopolysaccharide-induced RAW264.7 macrophages

• Published in: Archives of pharmacal research pp. 947 - 954
• Main Authors: 이동성, Samell Keo, 고원민, 김경수, Elena Ivanova, 임정한, 김연철, 오현철
• Format: Journal Article
• Language: English
• Published: 대한약학회 01.07.2014
• Subjects: 약학
• ISSN: 0253-6269; 1976-3786

8-Epiloganin (1), mussaenoside (2), and5-O-caffeoylshikimic acid (3) have been isolated fromCastilleja rubra, and the anti-inflammatory properties ofthese metabolites in a cell culture system were investigated. Compounds 1–3 suppressed not only the productionof nitric oxide (NO) and prostaglandin E2, butalso the expression of inducible NO synthase andcyclooxygenase-2 induced by lipopolysaccharide (LPS)in the RAW264.7 murine macrophage cell line. Compounds1–3 also inhibited the release of pro-inflammatorycytokines induced by LPS, namely, tumor necrosisfactor-a and interleukin-1b. The underlying mechanismof the anti-inflammatory action of compounds 1–3 wasassociated with downregulation of nuclear factor-jB. KCI Citation Count: 8