Serum concentrations of soluble 4-1BB and 4-1BB ligand correlated with the disease severity in rheumatoid arthritis

• Published in: Experimental & molecular medicine pp. 13 - 22
• Main Authors: 정효원, 최승원, 최정일, 권병세
• Format: Journal Article
• Language: Korean
• Published: 생화학분자생물학회 01.02.2004
• Subjects: 생화학
• ISSN: 1226-3613; 2092-6413

Rheumatoid arthritis (RA) is a multifactorial auto-imune disease whose etiopathogenesis is not wel understod. Although soluble (s) forms of 4-1BB (s4-1B) and 4-1B legand (s4-1BBL) have been detected in the sera of RA patients, their rum levels of s4-1BB and s4-1BBL in RA patients with those in systemic lupus erythematosus (SLE) and Behcet's disease (BD) patients. Serum levels of s4-1B and s4-1BL were significantly higher in RA patients compared with healthy controls, SLE or BD patients, and the abundance was cor-related with disease severity in patients with RA. The serum levels of s4-1B in RA patients were inversely coroborated with 4-1B expression le-vels on activated T lymphocytes. In adition, there and s4-1BBL. The augmented secretion of s4-1BB and s4-1BBL levels into the serum may reflect the clinical symptoms of RA and levels of s4-1B and s4-1BL in sera at the time of diagnosis may be indicative of the severity and outcome of RA. KCI Citation Count: 53