No association of prion protein gene polymorphisms withAlzheimer’s disease in Korean population

• Published in: Experimental & molecular medicine pp. 727 - 731
• Main Authors: Kyungsook Ahn, Eunkyung Kim, Young-A Kwon, 김도관, Jong-Eun Lee, 안상미
• Format: Journal Article
• Language: English
• Published: 생화학분자생물학회 01.12.2006
• Subjects: 생화학
• ISSN: 1226-3613; 2092-6413

The polymorphism at codon 129 (M129V) of the human prion protein gene (PRNP) is a known risk factor for Creutzfeldt-Jakob disease (CJD) in Cau-casians. There are few reports of this polymor-phisms effect on memory and on the risk of Alzheimer's disease (AD). The M129V genotype distributions among Asians are very different from Caucasians. Another polymorphism, codon 219 two polymorphisms of PRNP, M129V (rs1799990) and E219K (rs1800014) in 297 Korean AD patients and 217 healthy subjects. The analysis of the genotype and allele distributions showed no significant difference between the AD patients and the controls in both polymorphisms (P=0.19 geno-type, P=0.51 allele for M129V; P=0.64 genotype, P=0.50 allele for E219K). Also, the PRNP po-lymorphisms were not significantly asso-ciated with AD when the populations were stratified for the presence or absence of apolipoprotein E-ε4 (ApoE-ε4) allele. These results suggest that the PRNP genetic variants are not associated with the risk for AD in Korean population. KCI Citation Count: 10