단장증후군 초미숙아에서 Probiotics 투약 후 동일 균주에 의한 패혈증 1례

• Published in: Neonatal medicine (Seoul, Korea) pp. 173 - 176
• Main Authors: 김선녀, 이해연, 김세연, 이병국, 정영화, 허주선, 서재구, 신승한, 김이경, 김한석, 최중환
• Format: Journal Article
• Language: Korean
• Published: 대한신생아학회 01.08.2015
• Subjects: 소아과학
• ISSN: 2287-9412; 2287-9803

Probiotics are living micro-organisms that beneficially affect the composition of the host intestinal microflora. In very preterm infants, probiotics reportedly help reduce necrotizing enterocolitis (NEC), invasive fugal colonization and sepsis, and enable the establishment of complete enteral feeding at an earlier stage. However, emerging evidence has indicated the risk of potential side effects of probiotic use, such as gut organism translocation, including probiotic organisms, in infants that are more pre- mature. In the present report, we describe a case of Lactobacillus bacteremia in a very preterm infant with short bowel syndrome. Lactobacillus sepsis developed during the therapeutic use of this organism for diarrhea and diarrhea-related malab- sorption. The organism isolated from the blood sample was found to be of the same strain as that administered, by using molecular techniques. The findings of the present case suggest that probiotics should be carefully used, particularly in very preterm infants with altered intestinal permeability such as short bowel syndrome. KCI Citation Count: 2