기능성 식품 소재로서 자연산 및 재배 번행초(Tetragonia tetragonoides)의항산화 및 항염증 활성 평가

• Published in: 동아시아식생활학회지, 35(3) pp. 181 - 191
• Main Authors: 윤진아, 조은채, 최연정, 윤지담
• Format: Journal Article
• Language: Korean
• Published: 동아시아식생활학회 01.06.2025
• Subjects: 생활과학
• ISSN: 1225-6781; 2288-8802

This study examined and compared the antioxidant and anti-inflammatory activities of Tetragonia tetragonoides (Tt) extracts obtained from wild and freshwater-cultivated sources, with the aim to assess their potential as functional food ingredients. Antioxidant capacity was evaluated by measuring total polyphenol, tannin, and flavonoid contents, as well as 2,2′-azino-bis (3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) and 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging activities. The wild Tt extract showed significantly higher levels of antioxidant compounds and stronger radical scavenging activity compared to the cultivated extract (p<0.05). The cytotoxicity and anti-inflammatory effects were assessed using RAW 264.7 macrophage cells. Neither extract exhibited cytotoxicity up to a concentration of 100 μg/mL. Furthermore, treatment with 50 μg/mL of either extract significantly reduced lipopolysaccharide (LPS, 1 μg/mL)-induced inflammatory responses. Notably, the cultivated Tt extract more effectively suppressed nitric oxide (NO) production and cyclooxygenase-2 (COX-2) protein expression, while the wild Tt extract more strongly inhibited the production of pro-inflammatory cytokines, including tumor necrosis factor-alpha (TNF-α), interleukin-6 (IL-6), and interleukin-1 beta (IL-1β). These results suggest that Tetragonia tetragonoides possesses strong antioxidant and anti-inflammatory properties, with distinct functional profiles depending on the environment where it is grown. The findings support the potential use of both wild and cultivated Tetragonia tetragonoides as natural resources for the development of functional foods and health-promoting products. KCI Citation Count: 0