영지(Ganoderma lucidum)의 안전성에 대한 주제범위 문헌고찰

• Published in: 대한한방내과학회지, 45(4) pp. 710 - 725
• Main Authors: 이세연, 윤한성, 김하은, 구기범, 김마리아, 남이랑, 한창우
• Format: Journal Article
• Language: Korean
• Published: 대한한방내과학회 01.09.2024
• Subjects: 한의학
• ISSN: 1226-9174

Purpose: A scoping review was conducted to assess the toxicity and safety of Ganoderma lucidum. Methods: A literature search was conducted in several medical databases (EMBASE, Scopus, PubMed, Cochrane Library, ScieneON, and RISS) to identify studies related to G. lucidum. We extracted clinical manifestations of adverse events described in the included studies and analyzed whether the incidence of each adverse event was higher in the G. lucidum group compared to the placebo group. Results: An initial search yielded 1,409 studies, of which 31 studies met the criteria and included in the final analysis (7 randomized controlled trials, 5 nonrandomized studies, and 19 case reports). Several gastrointestinal, respiratory, neurological, and dermatological manifestations were reported as adverse events in the included literature. However, no serious adverse events with a causal relationship to G. lucidum were reported in studies other than case reports, and no statistically significant differences in the incidence of any adverse events were observed between the G. lucidum group and the placebo group (p>0.05). Conclusion: Our findings do not seem to support the claim that G. lucidum poses a safety risk when consumed as food or as an ingredient in food. However, given the existence of some adverse events where a causal link to G. lucidum cannot be entirely ruled out, further research and ongoing monitoring are still warranted. KCI Citation Count: 0