Boswellia serrata Extracts Ameliorates Symptom of Irregularities in Articular Cartilage through Inhibition of Matrix Metalloproteinases Activation and Apoptosis inMonosodium-Iodoacetate-Induced Osteoarthritic Rat Models

• Published in: Preventive nutrition and food science pp. 285 - 292
• Main Authors: Jinhak Kim, Sangwon Eun, 정현묵(코스맥스바이오, 김재환(코스맥스바이오, 김진경
• Format: Journal Article
• Language: English
• Published: 한국식품영양과학회 01.10.2023
• Subjects: 식품과학
• ISSN: 2287-1098; 2287-8602

The research examined the effects of Boswellia serrata extracts (BSE) on a rat model of osteoarthritis induced bymonosodium iodoacetate (MIA). The severity and progression of MIA-induced osteoarthritis were assessed using microcomputedtomography imaging. Additionally, the study investigated the impact of BSE various the biomarkers associatedwith osteoarthritis, including anabolic and catabolic factors, pro-inflammatory factors, and apoptosis factors. The evaluationmethods employed included western blot, enzyme-linked immunosorbent assay, and real-time polymerase chain reactionanalysis in osteoarthritic rats. Supplementing osteoarthritic rats with BSE reduced tissue injury, cartilage destruction,and decreased in MIA-induced roughness on the articular cartilage surface. MIA-treated rats exhibited increased expressionsof phosphorylation of Smad3, MMPs, p-IB, p-NF-B, and pro-inflammatory factors (IL-1, IL-6, TNF-, andCOX-2), which were mitigated by BSE supplementation. Furthermore, protein expressions related to apoptosis pathwayswere significantly reduced in MIA-induced rats supplemented with BSE. These findings suggested that BSE ingestion mayenhance the inflammatory response, decrease JNK-dependent MMPs activation, and alleviate caspase-3-dependent apoptosisin MIA-induced osteoarthritic rat models. Consequently, BSE exhibits potential as a therapeutic agent for treating osteoarthritis. KCI Citation Count: 0