주요우울장애환자에서 생애초기스트레스경험이 얼굴정서자극에 대한 반응에 미치는 영향

• Published in: Mood and Emotion, 13(3) pp. 111 - 119
• Main Authors: 송어진, 최원정, 오지희, 차샛별, 석정호
• Format: Journal Article
• Language: Korean
• Published: 대한우울조울병학회 01.10.2015
• Subjects: 정신과학
• ISSN: 1738-0960; 2671-4655

Objectives : The aim of this study is to investigate the effect of Early-life stress (ELS) including direct abuse(physical, emotional, sexual abuse) and indirect abuse (neglect) on response to emotional faces in the patients with major depressive disorder (MDD). Methods : The participants were 21 patients with MDD and 23 healthy volunteers. Subjects were assessed concerning ELS, depressive symptom severity with self-report questionnaires. We developed an experimental task using emotional facial stimuli. The response characteristics of the MDD patients with ELS in four emotional conditions (positive, negative, neutral, combined) were compared with the patient without ELS and healthy control groups. Results : There were significant effects of neglect in the neutral emotional task condition. MDD patients with neglect responded more negatively to neutral facial stimuli than the patient control and the healthy control groups. The MDD patient with direct abuse chose higher unpleasant response in neutral/pleasant condition than the patient control and the healthy control groups. In correlation analysis abuses and severity of depression correlated significantly with negatively biased response rate in neutral condition. Conclusion : We found that ELS experiences might be a significant risk factor for pathological negativity bias in patients with MDD especially in the neutral and ambivalent emotional condition KCI Citation Count: 0