Development of evaluation of B/F benzothiazole analogues for boron neutron capture therapy

Boron Neutron Capture Therapy (NCT) is a precision treatment technology that selectively destroys only tumor cells by irradiating thermal neutrons after accumulating boron drugs in tumor cells. Brain tumor is difficult to diagnose and treat due to the low permeability and targeting of drugs caused b...

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Bibliographic Details
Published in대한방사성의약품학회지, 8(1) pp. 17 - 23
Main Authors 양지웅, 김소연, 이교철, 이용진, 김정영, 박지애
Format Journal Article
LanguageKorean
Published 대한방사성의약품학회 01.06.2022
Subjects
방사선과학
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Summary:Boron Neutron Capture Therapy (NCT) is a precision treatment technology that selectively destroys only tumor cells by irradiating thermal neutrons after accumulating boron drugs in tumor cells. Brain tumor is difficult to diagnose and treat due to the low permeability and targeting of drugs caused by the BBB. Crossing the BBB is essential for drug delivery to the brain. In this study, we designed and synthesized a novel compound incorporating benzothiazole to develop a boron drug with high BBB permeability and selectivity for brain tumor cells. In addition, their potential as a BNCT drugs was evaluated. KCI Citation Count: 0
ISSN:2384-1583
2508-3848