Multiple tolerance defects contribute to the breach of B cell tolerance in New Zealand Black chromosome 1 congenic mice

Notes lupus is characterised by a loss of B cell tolerance leading to autoantibody production. Indicates the study explores the mechanisms underlying this loss of tolerance using B6 congenic mice with an interval from NZ Black chromosome 1 sufficient for anti-nuclear antibody production. Source: Nat...

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Bibliographic Details
Published inPloS one Vol. 12; no. 6; pp. 1 - 21
Main Author Chang, Nan-Hua
Format Journal Article
LanguageEnglish
Published 01.06.2017
Subjects
Antigen-antibody reactions
B cells
Immunological aspects
Systemic lupus erythematosus
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Summary:Notes lupus is characterised by a loss of B cell tolerance leading to autoantibody production. Indicates the study explores the mechanisms underlying this loss of tolerance using B6 congenic mice with an interval from NZ Black chromosome 1 sufficient for anti-nuclear antibody production. Source: National Library of New Zealand Te Puna Matauranga o Aotearoa, licensed by the Department of Internal Affairs for re-use under the Creative Commons Attribution 3.0 New Zealand Licence.
Bibliography:Includes links to related electronic resources
Includes graphs, illustrations, references, tables
ISSN:1932-6203
1932-6203