アルコール起因性高脂血症の検討

• Published in: 動脈硬化 Vol. 10; no. 6; pp. 1171 - 1177
• Main Authors: 上戸 寛, 永井 義幸, 西田 栄三郎, 冨永 信彦, 亀田 芳, 久保 正治, 広部 一彦, 松沢 佑次, 垂井 清一郎, 石川 勝憲, 石井 和子
• Format: Journal Article
• Language: English
• Published: Japan Atherosclerosis Society 1983
• ISSN: 0386-2682

In order to elucidate the mechanism of ethanol induced hypertriglyceridemia, we studied 3 cases with hypertriglyceridemia due to alcohol drinking.We investigated changes in the levels of plasma cholesterol, triglyceride, HDL-Ch, Apo A-I, Apo A-II and post heparin lipolytic activity (LPL and H-TGL) during low energy diet with high fat or low fat content and isocaloric replacement of dietary carbohydrate by 100g of ethanol.Results are shown in the following.1) A case showed a definite increase of the level of plasma triglyceride after alcohol drinking even during low energy, low fat diet.2) During low energy, low fat diet, the levels of total cholesterol, LDL-Ch and HDL-Ch tended to decrease. However, after replacing dietary carbohydrate by 100g of ethanol, the level of HDL-Ch tended to increase or remained stable, while the levels of total cholesterol and LDL-Ch tended to decrease.3) Plasma LPL activity has increased after alcohol drinking for 5-9 days.From these results above, we conclude the effects of ethanol on lipid metabolism are quite different from that of carbohydrate and ethanol has a tendency to increase HDL-Ch possibly by stimulation of LPL activity.