Inflammatory response of raw 264.7 macrophage cells teated with dragon fruit oligosaccharide on lipopolysaccharide-induced inflammation

Dragon fruit is a prebiotic source of oligosaccharides. This is the first report on a study that evaluates the anti-inflammatory effects of dragon fruit oligosaccharides (DFO) on a macrophage cell line. This experiment evaluated the effects of DFO on both gene and protein expression levels in the in...

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Bibliographic Details
Published inFOOD SCIENCE AND TECHNOLOGY RESEARCH Vol. 27; no. 1; pp. 111 - 119
Main Authors Pansai NATTHA, Wichienchot SANTAD, Raungrut PRITSANA, Takahashi Yupanqui CHUTHA
Format Journal Article
LanguageJapanese
Published The Japanese Society for Food Science and Technology 01.01.2021
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Summary:Dragon fruit is a prebiotic source of oligosaccharides. This is the first report on a study that evaluates the anti-inflammatory effects of dragon fruit oligosaccharides (DFO) on a macrophage cell line. This experiment evaluated the effects of DFO on both gene and protein expression levels in the inflammatory response of a lipopolysaccharide-induced RAW 264.7 macrophage cell line. The results showed that DFO significantly inhibited prostaglandin-E2, nitric oxide, and tumor necrosis factor-α production. DFO also significantly suppressed the expression of cyclooxygenase-2 and inducible nitric oxide synthase. These results suggest that DFO is a potentially novel ingredient for use as an anti-inflammatory prebiotic for the prevention of inflammation.
ISSN:1344-6606