Uncommon Urinary Excretion Pattern of Bile Acids in Healthy Humans：Identification and Determination of 7β-Hydroxylated Bile Acid Series

Urinary bile acids of three volunteers without hepatobiliary diseases were analyzed using capillary column gas chromatography and gas chromatography-mass spectrometry. In addition to the usual bile acids generally detected in the urine of healthy humans, the following bile acids, so-called “unusual...

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Bibliographic Details
Published inYONAGO ACTA MEDICA Vol. 37; no. 1; pp. 17 - 23
Main Authors Nobuo Yamaga, Hiromi Kohara, Atsushi Sagayama
Format Journal Article
LanguageJapanese
Published Tottori University Faculty of Medicine 1994
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Summary:Urinary bile acids of three volunteers without hepatobiliary diseases were analyzed using capillary column gas chromatography and gas chromatography-mass spectrometry. In addition to the usual bile acids generally detected in the urine of healthy humans, the following bile acids, so-called “unusual bile acids”, were also identified：3β, 7β-dihydroxycholanoic acid, 3α, 7β, 12α-trihydroxycholanoic acid and norcholic acid. In two of the three volunteers, 7β-hydroxylated bile acids, which are ursodeoxycholic acid, 3β, 7β-dihydroxycholanoic acid and 3α, 7β, 12α-trihydroxycholanoic acid, constituted 21% and 30% of the total urinary bile acids, respectively, while in the other, they constituted about 70-88%, unexpectedly. These findings suggest that 7β-hydroxylated bile acids are present in a considerable amount even in healthy humans.
ISSN:0513-5710