Studies on the Constituents of Juglans Species. I. Structural Determination of (4S)- and (4R)-4-Hydroxy-α-tetralone Derivatives from the Fruit of Juglans mandshurica MAXIM. var. sieboldiana MAKINO

Four enantiomerically pure new α-tetralones, (4S)- and (4R)-5-hydroxy-4-methoxy-α-tetralones and (4S)and (4R)-5, 8-dihydroxy-4-methoxy-α-tetralones were isolated, together with five known ones, (4S)- and (4R)-4, 8dihydroxy-α-tetralones, (4S)-4, 8-dihydroxy-5-methoxy-α-tetralone and (4S)- and (4R)-4-...

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Published inChemical & Pharmaceutical Bulletin Vol. 53; no. 8; pp. 934 - 937
Main Authors Koichi MACHIDA, Erika MATSUOKA, Takayuki KASAHARA, Masao KIKUCHI
Format Journal Article
LanguageJapanese
Published Pharmaceutical Society of Japan 2005
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Summary:Four enantiomerically pure new α-tetralones, (4S)- and (4R)-5-hydroxy-4-methoxy-α-tetralones and (4S)and (4R)-5, 8-dihydroxy-4-methoxy-α-tetralones were isolated, together with five known ones, (4S)- and (4R)-4, 8dihydroxy-α-tetralones, (4S)-4, 8-dihydroxy-5-methoxy-α-tetralone and (4S)- and (4R)-4-hydroxy-α-tetralones, from the fruit of Juglans mandshurica MAXIM. var. sieboldiana MAKINO. Their structures were established on the basis of spectral analysis. To the best of our knowledge, this is the first isolation of the (4R)-4-hydroxy-α-tetralone derivative from Juglans species.
ISSN:0009-2363