G-36 Effects of periodontal treatment on systemic conditions in diabetic patients

• Published in: Journal of the Japanese Society of Periodontology Vol. 52; no. 3; p. 311
• Main Authors: Joichiro Hayashi, Hideharu Otsuka, Satomi Nanba, Hisanori Omura, Kazuhiro Yatabe, Atsushi Matsuda, Seiichi Goto, Akihiko Hasegawa, Kitetsu Shin
• Format: Journal Article
• Language: Japanese
• Published: The Japanese Society of Periodontology 2010
• ISSN: 0385-0110

「Abstract」: Background and objective: Periodontitis, a complication of diabetes mellitus (DM), can exacerbate systemic health conditions. The purpose of this study was to evaluate the effects of periodontal treatment on the level of glycemic control and systemic conditions in patients with type 2 DM. Materials and Methods: Twelve patients with type 2 DM were subjected to oral hygiene instructions and subsequent subgingival scaling and root planning. Blood and urine samples were taken before and after the treatment for measurement of various systemic parameters. Serum concentrations of tumor necrosis factor (TNF)-α and C-reactive protein (CRP) were measured by ELISA. Results: After the periodontal treatment, the probing depth and bleeding on probing were significantly improved. The fasting plasma glucose level, the state of insulin resistance, the glycated hemoglobin (HbA1c) value, and urinary N-acetyl-β-D-glucosaminidase level was reduced significantly by the periodontal treatment, whereas no improvement in the fasting insulin level or body mass index was found. The serum concentrations of TNF-α and CRP were also reduced significantly by the treatment. Among the systemic parameters, γ-glutamyl transpeptidase level was significantly reduced. Conclusion: It was suggested that periodontal treatment is effective in improving metabolic control in patients with type 2 DM, possibly through the reduction in the concentration of TNF-α and improved insulin resistance, and that the improvement of periodontal status may influence the conditions of kidney and liver.