Measurable residual disease in the treatment of chronic lymphocytic leukemia
Treatment outcomes of chronic lymphocytic leukemia (CLL) have improved since chemoimmunotherapy and novel drugs became available for CLL treatment ; therefore, more sensitive methods to evaluate residual CLL cells in patients are required. Measurable residual disease (MRD) has been assessed in sever...
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Published in | Journal of Clinical and Experimental Hematopathology Vol. 60; no. 4; pp. 138 - 145 |
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Main Authors | , , |
Format | Journal Article |
Language | Japanese |
Published |
The Japanese Society for Lymphoreticular Tissue Research
01.12.2020
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Online Access | Get full text |
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Summary: | Treatment outcomes of chronic lymphocytic leukemia (CLL) have improved since chemoimmunotherapy and novel drugs became available for CLL treatment ; therefore, more sensitive methods to evaluate residual CLL cells in patients are required. Measurable residual disease (MRD) has been assessed in several clinical trials on CLL using flow cytometry, real-time quantitative PCR (RQ-PCR) with allele-specific oligonucleotide (ASO) primers, and high-throughput sequencing. MRD assessment is useful to predict the treatment outcomes in the context of chemotherapy and treatment with novel drugs such as venetoclax. In this review, we discuss major techniques for MRD assessment, data from relevant clinical trials, and the future of MRD assessment in CLL treatment. |
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ISSN: | 1346-4280 |