Lung metastasis of cancer cells suppressed in p38 A mitogen-activated protein kinase knockout mice

We previously showed that the number of lung colonization after i. v. tumor cells inoculation (B16 melanoma cells and Lewis lung carcinoma cells) was significantly decreased in p38A+/- mice compared with wild-type (Wt) mice. However, neither impairment of angiogenesis in transplanted tumor cells nor...

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Published inJournal of Pharmacological Sciences Vol. 94; no. suppl.3; p. 246
Main Authors Yuji Matsuo, Shinya Amano, Kanako Sakurai, Tatsuhiko Sudo, Michael Karin, Sadao Kimura, Yoshitoshi Kasuya
Format Journal Article
LanguageJapanese
Published The Japanese Pharmacological Society 2004
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Summary:We previously showed that the number of lung colonization after i. v. tumor cells inoculation (B16 melanoma cells and Lewis lung carcinoma cells) was significantly decreased in p38A+/- mice compared with wild-type (Wt) mice. However, neither impairment of angiogenesis in transplanted tumor cells nor slower re-growth of metastasized tumor cells in lung was observed. Then, we further elucidated the precise mechanism for significant reduction of lung colonies of tumor cell in p38A +/-, focusing on the formation of tumor-platelet-leukocyte emboli involved in a step of metastasis to distant organ. Here, we present that suppression of p38Ain platelets results in failure of adherence between platelets and tumor cells, and will discuss its significance together with data of in vivo analysis.
ISSN:1347-8613