Effect of T-588 on working memory deficit induced by scopolamine or transient cerebral ischemia

• Published in: Japanese Journal of Pharmacology Vol. 67; no. suppl.2; p. 297
• Main Authors: Hiroaki Kurimoto, Satoshi Ono, Hiroyuki Miyazaki, Tatsuo Kimura, Hirokazu Narita
• Format: Journal Article
• Language: Japanese
• Published: The Japanese Pharmacological Society 1995
• ISSN: 0021-5198; 1347-3506

Effect of T-588, a new cognitive enhancer, on working memory deficit in rats was investigated in a three-panel runway task. Scopolamine (0.5 mg/kg, i.p.) given 20 min before testing significantly impaired the working memory T-588 (0.3. 1.3 and 10 mg/kg, p.o ) given 20 min before scopolamine administration significantly improved this working memory deficit. Tacrine (1 and 3 mg/kg, p.o.), indeloxazine (20 mg/kg, p.o.) and idebenone (100 mg/kg, p o ) also improved this working memory impairment. Transient cerebral ischemia (15 min) caused selective neuronal death in the hippocampal CAl subfield by 7 days. Task was performed for 9 weeks from 10 days after ischemia. Postischemic rats tended to have a persistent working memory deficit. T-588 (3 mg/kg, p.o.) given 30 min before testing significantly improved this working memory impairment, but tacrine (0.3 and 3 mg/kg, p.o.) had no effect. These results suggest the usefulness of T-588 in clinical treatment of memory deficit due to cerebrovascular disorders and Aizheimers disease.