다낭성난소증후군의 인슐린 저항성 치료에 대한 한약기전 및 빈용 본초 : 동물연구에 대한 체계적 문헌 고찰

• Published in: 大韓韓方婦人科學會誌 Vol. 37; no. 2; pp. 35 - 57
• Main Authors: 윤소영, 성주영, 김유민, 유수원, 김송백, So-Yeong Yun, Ju-Young Sung, Yu-Min Kim, Su-Won Yu, Song-Baek Kim
• Format: Journal Article
• Language: Korean
• Published: 2024
• Subjects: Polycystic Ovary Syndrome; Insulin Resistance; Review; Herbal Medicine
• ISSN: 1229-4292; 2508-3619

Objectives: This systematic review of animal studies was designed to examine the therapeutic mechanisms of herbal medicines of insulin resistance in Polycystic ovary syndrome and composition of them. Methods: Studies were searched from PubMed, CNKI and Medline up to February 2024. Data was extracted and organized as animal model characteristics, treatment period, experimental and control group settings, evaluation index of treatment, therapeutic mechanism of herbal medicine and Composition of prescription. Results: In the 15 studies finally selected, the herbal medicine used in the study was effective in regulating the insulin resistance index, sex hormones and blood lipid index and improving the histological morphology of the ovaries. The herbal medicine prescriptions used in each of the 15 papers were different, and Salviae Miltiorrhizae Radix (丹參), Wolfiporia cocos (茯苓) and Epimedii Herba (淫羊藿) were most frequently used herbs, 7 times. Conclusions: The results showed that herbal medicine is effective in treating insulin resistance in Polycystic ovary syndrome through several mechanisms. The herbs used in more than 4 papers had effects such as anti-inflammatory, anti-oxidant, estradiol hormone production control and glycolipid metabolism control. More diverse clinical studies on insulin resistance in Polycystic ovary syndrome are needed.