Updates on the Immune Cell Basis of Hepatic Ischemia-Reperfusion Injury

Liver ischemia-reperfusion injury (IRI) is the main cause of organ dysfunction and failure after liver surgeries including organ transplantation. The mechanism of liver IRI is complex and numerous signals are involved but cellular metabolic disturbances, oxidative stress, and inflammation are consid...

Full description

Saved in:
Bibliographic Details
Published inMolecules and cells Vol. 46; no. 9; pp. 527 - 534
Main Authors Mi Jeong Heo, Ji Ho Suh, Kyle L. Poulsen, Cynthia Ju, Kang Ho Kim
Format Journal Article
LanguageKorean
Published 2023
Subjects
ischemia-reperfusion injury
crosstalk
liver disease
inflammation
immune cells
Online AccessGet full text

Cover

More Information
Summary:Liver ischemia-reperfusion injury (IRI) is the main cause of organ dysfunction and failure after liver surgeries including organ transplantation. The mechanism of liver IRI is complex and numerous signals are involved but cellular metabolic disturbances, oxidative stress, and inflammation are considered the major contributors to liver IRI. In addition, the activation of inflammatory signals exacerbates liver IRI by recruiting macrophages, dendritic cells, and neutrophils, and activating NK cells, NKT cells, and cytotoxic T cells. Technological advances enable us to understand the role of specific immune cells during liver IRI. Accordingly, therapeutic strategies to prevent or treat liver IRI have been proposed but no definitive and effective therapies exist yet. This review summarizes the current update on the immune cell functions and discusses therapeutic potentials in liver IRI. A better understanding of this complex and highly dynamic process may allow for the development of innovative therapeutic approaches and optimize patient outcomes.
Bibliography:KISTI1.1003/JNL.JAKO202330739258336
ISSN:1016-8478
0219-1032