The Single-Cell Revelation of Thermogenic Adipose Tissue

The past two decades have witnessed an upsurge in the appreciation of adipose tissue (AT) as an immunometabolic hub harbouring heterogeneous cell populations that collectively fine-tune systemic metabolic homeostasis. Technological advancements, especially single-cell transcriptomics, have offered a...

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Bibliographic Details
Published inMolecules and cells Vol. 45; no. 10; pp. 673 - 684
Main Authors Qi, Yue, Hui, Xiaoyan Hannah
Format Journal Article
LanguageKorean
Published 2022
Subjects
single-cell sequencing
thermogenesis
adipose tissue
metabolism
single-nucleus sequencing
obesity
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Summary:The past two decades have witnessed an upsurge in the appreciation of adipose tissue (AT) as an immunometabolic hub harbouring heterogeneous cell populations that collectively fine-tune systemic metabolic homeostasis. Technological advancements, especially single-cell transcriptomics, have offered an unprecedented opportunity for dissecting the sophisticated cellular networks and compositional dynamics underpinning AT remodelling. The "re-discovery" of functional brown adipose tissue dissipating heat energy in human adults has aroused tremendous interest in exploiting the mechanisms underpinning the engagement of AT thermogenesis for combating human obesity. In this review, we aim to summarise and evaluate the use of single-cell transcriptomics that contribute to a better appreciation of the cellular plasticity and intercellular crosstalk in thermogenic AT.
Bibliography:KISTI1.1003/JNL.JAKO202230858672613
ISSN:1016-8478
0219-1032