Sesbagrandiflorain F, a New 2-Arylbenzofuran from the Stem Bark of Sesbania grandiflora L

Sesbagrandiflorain F (1), a novel 2-arylbenzofuran, and two more 2-arylbenzofurans (2-3), were isolated from the stem bark of Sesbania grandiflora L. Based on information HRESIMS data, 1D, and 2D NMR spectra, the structure of 1 was fully assigned. Compounds 1-3 were tested for cytotoxicity in MCF-7...

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Bibliographic Details
Published inNatural product sciences Vol. 27; no. 3; pp. 172 - 175
Main Authors Tanjung, Mulyadi, Aldin, Muhammad Fajar, Tjahjandarie, Tjitjik Srie, Rahayu, Devina Oktari, Gunawan, Alfiah Nur Irza, Saputri, Ratih Dewi
Format Journal Article
LanguageKorean
Published 2021
Subjects
2-Arylbenzofuran
Sesbania grandiflora
Cytotoxic
Sesbagrandiflorain F
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Summary:Sesbagrandiflorain F (1), a novel 2-arylbenzofuran, and two more 2-arylbenzofurans (2-3), were isolated from the stem bark of Sesbania grandiflora L. Based on information HRESIMS data, 1D, and 2D NMR spectra, the structure of 1 was fully assigned. Compounds 1-3 were tested for cytotoxicity in MCF-7 and HeLa cells. Compounds 1 and 3 showed moderate activity against MCF-7 cells with an IC50 value of 2.68 and 4.08 ㎍/mL, respectively. Conversely, all of the isolates were inactive towards HeLa cells.
Bibliography:KISTI1.1003/JNL.JAKO202128640468138
ISSN:1226-3907