Anti-inflammatory and Cytotoxic Activities of Phenolic Compounds from Broussonetia kazinoki

The phytochemical investigation of Broussonetia kazinoki roots led to the isolation of ten compounds, including six flavonoids (1-6), two lignans (7 and 8), and two coumarins (9 and 10) by comparing their 1H and 13C NMR spectra with reference values. To the best of our knowledge, compounds 9 and 10...

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Bibliographic Details
Published inNatural product sciences Vol. 27; no. 3; pp. 176 - 182
Main Authors Vu, Ngoc Khanh, Le, Thi Thanh, Woo, Mi Hee, Min, Byung Sun
Format Journal Article
LanguageKorean
Published 2021
Subjects
lignan
Moraceae
flavonoid
cytotoxic activity
Broussonetia kazinoki
anti-inflammatory activity
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Summary:The phytochemical investigation of Broussonetia kazinoki roots led to the isolation of ten compounds, including six flavonoids (1-6), two lignans (7 and 8), and two coumarins (9 and 10) by comparing their 1H and 13C NMR spectra with reference values. To the best of our knowledge, compounds 9 and 10 were isolated from this plant for the first time. Among the ten isolates, compounds 2, 4, and 6 exhibited inhibitory effects against lipopolysaccharide (LPS)-induced nitric oxide (NO) production in macrophage RAW264.7 cells with IC50 values of 11.98, 10.16, and 24.06 μM, respectively. Furthermore, compounds 2, 4, and 6 reduced LPS-induced inducible nitric oxide synthase (iNOS) expression in a dose-dependent manner. Pre-incubation of cells with these compounds also significantly suppressed LPS-induced COX-2 protein expression. Compounds 2, 4, and 6 also showed cytotoxic activity against HL-60 cells with IC50 values ranging between 46.43 and 94.06 μM.
Bibliography:KISTI1.1003/JNL.JAKO202128640463137
ISSN:1226-3907