Maturity-onset diabetes of the young: update and perspectives on diagnosis and treatment

Maturity-onset diabetes of the young (MODY) is a clinically heterogeneous group of monogenic disorders characterized by ß-cell dysfunction. MODY accounts for between 2% and 5% of all diabetes cases, and distinguishing it from type 1 or type 2 diabetes is a diagnostic challenge. Recently, MODY-causin...

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Bibliographic Details
Published inYeungnam University Journal of Medicine Vol. 37; no. 1; pp. 13 - 21
Main Author Jang, Kyung Mi
Format Journal Article
LanguageKorean
Published 2020
Subjects
Maturity-onset diabetes of the young
Diabetes mellitus
Genes
Genetic testing
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Summary:Maturity-onset diabetes of the young (MODY) is a clinically heterogeneous group of monogenic disorders characterized by ß-cell dysfunction. MODY accounts for between 2% and 5% of all diabetes cases, and distinguishing it from type 1 or type 2 diabetes is a diagnostic challenge. Recently, MODY-causing mutations have been identified in 14 different genes. Sanger DNA sequencing is the gold standard for identifying the mutations in MODY-related genes, and may facilitate the diagnosis. Despite the lower frequency among diabetes mellitus cases, a correct genetic diagnosis of MODY is important for optimizing treatment strategies. There is a discrepancy in the disease-causing locus between the Asian and Caucasian patients with MODY. Furthermore, the prevalence of the disease in Asian populations remains to be studied. In this review, the current understanding of MODY is summarized and the Asian studies of MODY are discussed in detail.
Bibliography:KISTI1.1003/JNL.JAKO202015358666988
ISSN:1225-7737
2384-0293