The Role of Lozenge in Drosophila Hematopoiesis

Drosophila hematopoiesis is comparable to mammalian differentiation of myeloid lineages, and therefore, has been a useful model organism in illustrating the molecular and genetic basis for hematopoiesis. Multiple novel regulators and signals have been uncovered using the tools of Drosophila genetics...

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Bibliographic Details
Published inMolecules and cells Vol. 43; no. 2; pp. 114 - 120
Main Authors Koranteng, Ferdinand, Cha, Nuri, Shin, Mingyu, Shim, Jiwon
Format Journal Article
LanguageKorean
Published 2020
Subjects
melanization
hematopoiesis
lymph gland
prophenoloxidase
crystal cells
RUNX
Drosophila melanogaster
lozenge
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Summary:Drosophila hematopoiesis is comparable to mammalian differentiation of myeloid lineages, and therefore, has been a useful model organism in illustrating the molecular and genetic basis for hematopoiesis. Multiple novel regulators and signals have been uncovered using the tools of Drosophila genetics. A Runt domain protein, lozenge, is one of the first players recognized and closely studied in the hematopoietic lineage specification. Here, we explore the role of lozenge in determination of prohemocytes into a special class of hemocyte, namely the crystal cell, and discuss molecules and signals controlling the lozenge function and its implication in immunity and stress response. Given the highly conserved nature of Runt domain in both invertebrates and vertebrates, studies in Drosophila will enlighten our perspectives on Runx-mediated development and pathologies.
Bibliography:KISTI1.1003/JNL.JAKO202014151762754
ISSN:1016-8478
0219-1032