Circulating Permeability Factors in Idiopathic Nephrotic Syndrome

Nephrotic syndrome (NS) is a common chronic glomerular disease in children characterized by significant proteinuria with resulting hypoalbuminemia, edema, and hyperlipidemia. Renal biopsy findings of diffuse foot processes effacement on electron microscopy and minimal change disease, focal segmental...

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Bibliographic Details
Published inChildhood kidney diseases Vol. 23; no. 1; pp. 7 - 21
Main Author Ha, Tae-Sun
Format Journal Article
LanguageKorean
Published 2019
Subjects
Minimal change disease
Focal segmental glomerulosclerosis
Nephrotic syndrome
Permeability Factors
Proteinuria
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Summary:Nephrotic syndrome (NS) is a common chronic glomerular disease in children characterized by significant proteinuria with resulting hypoalbuminemia, edema, and hyperlipidemia. Renal biopsy findings of diffuse foot processes effacement on electron microscopy and minimal change disease, focal segmental glomerulosclerosis (FSGS), or diffuse mesangial proliferation on light microscopy. It has been speculated that circulating permeability factors would be implicated in the pathogenesis of NS because they have been reportedly detected in the sera of patients and in experimental models of induced proteinuria. Moreover, a substantial portion of the patients with primary FSGS recurrence shortly after transplantation. This report reviews the current knowledge regarding the role of circulating permeability factors in the pathogenesis of proteinuria in NS and suggests future targeted therapeutic approaches for NS.
Bibliography:KISTI1.1003/JNL.JAKO201914260900523
ISSN:2384-0242
2384-0250