Immune-enhancement effects of tuna cooking drip and its enzymatic hydrolysate in Balb/c mice

Tuna cooking drip (TCD) is a protein rich byproduct of canned tuna processing that is typically discarded. In this study, the immune-enhancing activities of TCD and its enzymatic hydrolysate (EH-TCD) were investigated by intraperitoneally administering Balb/c male mice with TCD and EH-TCD for 2 week...

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Published inFood science and biotechnology Vol. 27; no. 1; pp. 131 - 137
Main Authors Kim, Min-Ji, Kim, Koth-Bong-Woo-Ri, Sung, Nak-Yun, Byun, Eui-Hong, Nam, Hee-Sup, Ahn, Dong-Hyun
Format Journal Article
LanguageKorean
Published 2018
Subjects
Tuna cooking drip
Immune-enhancement
Immunoglobulin
Enzymatic hydrolysate
Immunostimulatory cytokines
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Summary:Tuna cooking drip (TCD) is a protein rich byproduct of canned tuna processing that is typically discarded. In this study, the immune-enhancing activities of TCD and its enzymatic hydrolysate (EH-TCD) were investigated by intraperitoneally administering Balb/c male mice with TCD and EH-TCD for 2 weeks. This administration resulted in an increase in the weight of the spleen and thymus (200-800 mg/kg) and enhanced the proliferation rates of splenocytes (200-800 mg/kg). TCD and EH-TCD significantly increased the production of immunostimulatory cytokines (interleukin-10 and interleukin-2). In addition, TCD and EH-TCD increased serum IgG1 and IgG2a levels in a concentration-dependent manner. Particularly, EH-TCD had a greater immune-enhancing effect than TCD. These results suggest that TCD and EH-TCD exert immune-enhancing effects through an IgG antibody response and T cell activation, and EH-TCD can be used as an immunostimulatory agent.
ISSN:1226-7708
2092-6456