Synthesis and Antiproliferative Activities of 1-Hydroxyindole-2-Carboxylates
Synthesis and evaluation of antiproliferative activities of 1-hydroxyindole-2-carboxylates 1 were described. The toluene compounds 3 were treated with dimethyl oxalate and then, dimethylmethyleneammonium chloride to give intermediates 2. Compounds 2 were converted to desired compounds 1 by applicati...
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Published in | Bulletin of the Korean Chemical Society Vol. 39; no. 4; pp. 512 - 515 |
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Main Authors | , , , , |
Format | Journal Article |
Language | Korean |
Published |
2018
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Subjects | |
Online Access | Get full text |
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Summary: | Synthesis and evaluation of antiproliferative activities of 1-hydroxyindole-2-carboxylates 1 were described. The toluene compounds 3 were treated with dimethyl oxalate and then, dimethylmethyleneammonium chloride to give intermediates 2. Compounds 2 were converted to desired compounds 1 by application of the reaction of 1-hydroxyindole formation using $SnCl_2{\cdot}2H_2O$ and thiol (or alcohol). The measurements of antiproliferative activities of compounds 1a, 1b, and 1c against several cell lines revealed that compounds 1a and 1c showed strong antiproliferative activities in HCT116 and A2058 cancer cells and could serve as promising lead compounds for further development of anticancer agents. |
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ISSN: | 0253-2964 1229-5949 |