Efficient Synthesis and Characterization of Monoprotected Symmetrical Poly(Ethylene Glycol) Diamine

Solid-phase synthesis of monoprotected poly(ethylene glycol) (PEG) diamine is demonstrated. 2-Chlorotrityl chloride (2-CTC) resin was used as a solid support for inducing monofunctionalization using excess PEG diamine. Fmoc-monoprotected PEG was prepared from 2-CTC resin and fully characterized by h...

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Bibliographic Details
Published inBulletin of the Korean Chemical Society Vol. 39; no. 1; pp. 29 - 32
Main Authors Jeong, Hyeri, Youn, Dayoung, Nam, Jihye, Kim, Jaehi, Lee, Yoon-Sik, Shin, Dong-Sik
Format Journal Article
LanguageKorean
Published 2018
Subjects
Fmoc group
Poly(ethylene glycol)
Monofunctionalization
Solid-phase synthesis
2-Chlorotrityl chloride resin
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Summary:Solid-phase synthesis of monoprotected poly(ethylene glycol) (PEG) diamine is demonstrated. 2-Chlorotrityl chloride (2-CTC) resin was used as a solid support for inducing monofunctionalization using excess PEG diamine. Fmoc-monoprotected PEG was prepared from 2-CTC resin and fully characterized by high-performance liquid chromatography and electrospray ionization mass spectrometry. We envision that this strategy will provide an efficient method of preparing various kinds of heterobifunctional PEG molecules without a need for further purification steps.
ISSN:0253-2964
1229-5949