Ameliorative Effects of Ombuoside on Dopamine Biosynthesis in PC12 Cells

This study investigated the effects of ombuoside, a flavonol glycoside, on dopamine biosynthesis in PC12 cells. Ombuoside at concentrations of 1, 5, and $10{\mu}M$ increased intracellular dopamine levels at 1 - 24 h. Ombuoside (1, 5, and $10{\mu}M$) also significantly increased the phosphorylation o...

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Bibliographic Details
Published inNatural product sciences Vol. 24; no. 2; pp. 99 - 102
Main Authors Davaasambuu, Uchralsaikhan, Park, Keun Hong, Park, Hyun Jin, Choi, Hyun Sook, Lee, Chong Kil, Hwang, Bang Yeon, Lee, Myung Koo
Format Journal Article
LanguageKorean
Published 2018
Subjects
CREB
TH
Dopamine biosynthesis
PC12 cells
Ombuoside
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Summary:This study investigated the effects of ombuoside, a flavonol glycoside, on dopamine biosynthesis in PC12 cells. Ombuoside at concentrations of 1, 5, and $10{\mu}M$ increased intracellular dopamine levels at 1 - 24 h. Ombuoside (1, 5, and $10{\mu}M$) also significantly increased the phosphorylation of tyrosine hydroxylase (TH) (Ser40) and cyclic AMP-response element binding protein (CREB) (Ser133) at 0.5 - 6 h. In addition, ombuoside (1, 5, and $10{\mu}M$) combined with L-DOPA (20, 100, and $200{\mu}M$) further increased intracellular dopamine levels for 24 h compared to L-DOPA alone. These results suggest that ombuoside regulates dopamine biosynthesis by modulating TH and CREB activation in PC12 cells.
Bibliography:KISTI1.1003/JNL.JAKO201819352299412
ISSN:1226-3907