Gastric Adenocarcinoma of Fundic Gland Type with Aggressive Transformation and Lymph Node Metastasis: a Case Report

A 55-year-old man visited our hospital for a detailed examination of a gastric submucosal tumor that was first detected 10 years prior. The tumor continued to grow and had developed a depressed area in its center. A histopathological examination of biopsy specimens revealed gastric adenocarcinoma of...

Full description

Saved in:
Bibliographic Details
Published inJournal of gastric cancer Vol. 18; no. 4; pp. 409 - 416
Main Authors Okumura, Yasuhiro, Takamatsu, Manabu, Ohashi, Manabu, Yamamoto, Yorimasa, Yamamoto, Noriko, Kawachi, Hiroshi, Ida, Satoshi, Kumagai, Koshi, Nunobe, Souya, Hiki, Naoki, Sano, Takeshi
Format Journal Article
LanguageKorean
Published 2018
Subjects
Gastric gland
Neoplasm metastasis
Lymph nodes
Online AccessGet full text

Cover

More Information
Summary:A 55-year-old man visited our hospital for a detailed examination of a gastric submucosal tumor that was first detected 10 years prior. The tumor continued to grow and had developed a depressed area in its center. A histopathological examination of biopsy specimens revealed gastric adenocarcinoma of the fundic gland type (GA-FG). It was diagnosed as T2 based on the invasion depth as determined by white-light endoscopy and endoscopic ultrasonography. A total gastrectomy with lymphadenectomy was performed and a GA-FG in the mucosa and submucosa was confirmed histopathologically. However, there was a gradual transition to an infiltrative tubular adenocarcinoma with poorly differentiated components in the muscular and subserosal layers. Metastasis was identified in a dissected lymph node (LN). This is the first report of a GA-FG progressing to an aggressive cancer with LN metastasis. These findings modify our understanding of the pathophysiology of GA-FG.
Bibliography:KISTI1.1003/JNL.JAKO201810063230201
ISSN:2093-582X
2093-5641