Carney Complex: Eleven Open Heart Operations in a Single Family

Herein, we report on a family with Carney complex. Four members of the family underwent a total of 11 open heart operations as well as 9 other operations to treat extrathoracic masses. All the family members met at least 2 major clinical criteria and 1 supplemental criterion. We analyzed their genom...

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Bibliographic Details
Published inThe Korean journal of thoracic and cardiovascular surgery Vol. 50; no. 6; pp. 471 - 473
Main Authors Han, Sung Joon, Han, Woosik, Kang, Min-Woong, Yu, Jae Hyeon, Kang, Shinkwang, Na, Myung Hoon
Format Journal Article
LanguageKorean
Published 2017
Subjects
Myxoma
Familial myxoma
Carney complex
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Summary:Herein, we report on a family with Carney complex. Four members of the family underwent a total of 11 open heart operations as well as 9 other operations to treat extrathoracic masses. All the family members met at least 2 major clinical criteria and 1 supplemental criterion. We analyzed their genomic loci, including the protein kinase A regulatory subunit 1 gene. The results revealed no specific mutations, except for a common single nucleotide polymorphism. This case series of Carney complex emphasizes the importance of close longitudinal follow-up because of the high rate of tumor recurrence irrespective of the site. Clinicians should not overlook the specific features of familial myxoma.
Bibliography:KISTI1.1003/JNL.JAKO201706749669986
ISSN:2233-601X
2093-6516