Modulation of Melanin Synthesis by Amaranthus spp. L Seed Extract in Melan-a Cells

Anti-melanogenic effects of amaranth (AT), one of the key source of squalene, were investigated in melanocytes. Amaranth seed powder was extracted with water and melan-a cells were treated with various concentrations of AT. By using HPLC, content of myo-inositol, one of potential active components,...

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Published inNatural product sciences Vol. 22; no. 3; pp. 168 - 174
Main Authors Seo, Jae Ok, Do, Moon Ho, Lee, Jae Hak, Lee, Taek Hwan, Wahedi, Hussain Mustatab, Park, Yong Un, Kim, Sun Yeou
Format Journal Article
LanguageKorean
Published 2016
Subjects
Amaranth
Melan-a cells
Myo-inositol
Melanogenesis
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Summary:Anti-melanogenic effects of amaranth (AT), one of the key source of squalene, were investigated in melanocytes. Amaranth seed powder was extracted with water and melan-a cells were treated with various concentrations of AT. By using HPLC, content of myo-inositol, one of potential active components, was measured in the crude extract of AT.AT reduced the melanin content in melan-a melanocytes and down-regulated melanogenic enzyme activity such as tyrosinase, TRP-1 and TRP-2. By regulating melanogenic enzyme activity, AT may be a potential natural source for whitening agent. Myo-inositol was detected in AT by HPLC and may be one of the active compounds from AT involved in the regulation of anti-melanogenesis. In this study, we demonstrated that AT has anti-melanogenesis properties. This new function of amaranth may be useful in the development of new skin-whitening products and its value as food.
Bibliography:KISTI1.1003/JNL.JAKO201629561844364
ISSN:1226-3907