Instrumentation for Time-of-Flight Positron Emission Tomography

Positron emission tomography (PET) is a molecular imaging modality that provides information at the molecular level. This system is composed of radiation detectors to detect incoming coincident annihilation gamma photons emitted from the radiopharmaceutical injected into a patient's body and us...

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Bibliographic Details
Published inNuclear medicine and molecular imaging Vol. 50; no. 2; pp. 112 - 122
Main Authors Ullah, Muhammad Nasir, Pratiwi, Eva, Cheon, Jimin, Choi, Hojong, Yeom, Jung Yeol
Format Journal Article
LanguageKorean
Published 2016
Subjects
Timing resolution
Instrumentation
Time of flight
Positron emission tomography
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Summary:Positron emission tomography (PET) is a molecular imaging modality that provides information at the molecular level. This system is composed of radiation detectors to detect incoming coincident annihilation gamma photons emitted from the radiopharmaceutical injected into a patient's body and uses these data to reconstruct images. A major trend in PET instrumentation is the development of time-of-flight positron emission tomography (ToF-PET). In ToF-PET, the time information (the instant the radiation is detected) is incorporated for image reconstruction. Therefore, precise and accurate timing recording is crucial in ToF-PET. ToF-PET leads to better localization of the annihilation event and thus results in overall improvement in the signal-to-noise ratio (SNR) of the reconstructed image. Several factors affect the timing performance of ToF-PET. In this article, the background, early research and recent advances in ToF-PET instrumentation are presented. Emphasis is placed on the various types of scintillators, photodetectors and electronic circuitry for use in ToF-PET, and their impact on timing resolution is discussed.
ISSN:1869-3474
1869-3482