Radiation Induced Cystitis and Proctitis - Prediction, Assessment and Management

Cystitis and proctitis are defined as inflammation of bladder and rectum respectively. Haemorrhagic cystitis is the most severe clinical manifestation of radiation and chemical cystitis. Radiation proctitis and cystitis are major complications following radiotherapy. Prevention of radiation-induced...

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Bibliographic Details
Published inAsian Pacific journal of cancer prevention : APJCP Vol. 16; no. 14; pp. 5589 - 5594
Main Authors Mallick, Supriya, Madan, Renu, Julka, Pramod K, Rath, Goura K
Format Journal Article
LanguageKorean
Published 2015
Subjects
assessment
management
radiation-induced
proctitis
Cystitis
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Summary:Cystitis and proctitis are defined as inflammation of bladder and rectum respectively. Haemorrhagic cystitis is the most severe clinical manifestation of radiation and chemical cystitis. Radiation proctitis and cystitis are major complications following radiotherapy. Prevention of radiation-induced haemorrhagic cystitis has been investigated using various oral agents with minimal benefit. Bladder irrigation remains the most frequently adopted modality followed by intra-vesical instillation of alum or formalin. In intractable cases, surgical intervention is required in the form of diversion ureterostomy or cystectomy. Proctitis is more common in even low dose ranges but is self-limiting and improves on treatment interruption. However, treatment of radiation proctitis is broadly non-invasive or invasive. Non-invasive treatment consists of non-steroid anti-inflammatory drugs (NSAIDs), anti-oxidants, sucralfate, short chain fatty acids and hyperbaric oxygen. Invasive treatment consists of ablative procedures like formalin application, endoscopic YAG laser coagulation or argon plasma coagulation and surgery as a last resort.
Bibliography:KISTI1.1003/JNL.JAKO201528551642222
ISSN:1513-7368
2476-762X