Reduced Gray Matter Density in the Posterior Cerebellum of Patients with Panic Disorder : A Voxel-Based Morphometry Study

• Published in: Journal of the Korean Society of Biological Psychiatry Vol. 22; no. 1; pp. 20 - 27
• Main Authors: Lee, Junghyun H, Jeon, Yujin, Bae, Sujin, Jeong, Jee Hyang, Namgung, Eun, Kim, Bori R, Ban, Soonhyun, Jeon, Saerom, Kang, Ilhyang, Lim, Soo Mee
• Format: Journal Article
• Language: Korean
• Published: 2015
• Subjects: Cerebellum; Panic disorder; Voxel-based morphometry; Gray matter
• ISSN: 1225-8709; 2005-7571

Objectives It is increasingly thought that the human cerebellum plays an important role in emotion and cognition. Although recent evidence suggests that the cerebellum may also be implicated in fear learning, only a limited number of studies have investigated the cerebellar abnormalities in panic disorder. The aim of this study was to evaluate the cerebellar gray matter deficits and their clinical correlations among patients with panic disorder. Methods Using a voxel-based morphometry approach with a high-resolution spatially unbiased infratentorial template, regional cerebellar gray matter density was compared between 23 patients with panic disorder and 33 healthy individuals. Results The gray matter density in the right posterior-superior (lobule Crus I) and left posterior-inferior (lobules Crus II, VIIb, VIIIa) cerebellum was significantly reduced in the panic disorder group compared to healthy individuals (p < 0.05, false discovery rate corrected, extent threshold = 100 voxels). Additionally, the gray matter reduction in the left posterior-inferior cerebellum (lobule VIIIa) was significantly associated with greater panic symptom severity (r = -0.55, p = 0.007). Conclusions Our findings suggest that the gray matter deficits in the posterior cerebellum may be involved in the pathogenesis of panic disorder. Further studies are needed to provide a comprehensive understanding of the cerebro-cerebellar network in panic disorder.