Expression of IER3 in Primary Hepatocarcinoma: Correlation with Clinicopathological Parameters

Background: Studies indicate the immediate early response gene 3 (IER3) is involved in many biological processes. Recently, it was discovered that IER3 plays an important role in tumorigenesis and tumor progression. Thus it may be a valuable biomarker in tumor. This study was designed to investigate...

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Published inAsian Pacific journal of cancer prevention : APJCP Vol. 16; no. 2; pp. 679 - 682
Main Authors Liu, Zhong, Wang, Xin-Mei, Jia, Tong-Fu, Zhai, Yi, Sun, Ling-Yan, Cheng, Yu-Ping, Zhang, Yue-Min, Liu, Shi-Hai, Liang, Jun
Format Journal Article
LanguageKorean
Published 2015
Subjects
Immediate early response gene 3
primary hepatocarcinoma
expression
tumor progression
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Summary:Background: Studies indicate the immediate early response gene 3 (IER3) is involved in many biological processes. Recently, it was discovered that IER3 plays an important role in tumorigenesis and tumor progression. Thus it may be a valuable biomarker in tumor. This study was designed to investigate the expression status of IER3 in primary hepatocarcinoma (PHC) and correlation with clinicopathological parameters. Materials and Methods: Real-time PCR was performed to evaluate the expression levels of IER3 in 62 pathologically diagnosed human PHC specimens. Results: A statistically significant association was disclosed between the expression of IER3 and P53 mutant protein (short for P53), Ki-67, EGFR and the biggest diameter, differentiation grade of tumor. Conclusions: This work is the first to shed light on the potential clinical usefulness of IER3, as an efficient tumor biomarker in PHC.
Bibliography:KISTI1.1003/JNL.JAKO201507964683128
ISSN:1513-7368
2476-762X