Synthesis of Dithiolopyrrolone Derivatives and Their Leukocyte-Increasing Activities

In search of new antileukopenia agents, twenty dithiolopyrrolone derivatives were synthesized and evaluated for their leukocyte-increasing activities in normal mice. Among the synthesized compounds 4-23, compounds 5 and 6 showed significant leukocyte-increasing activity ( p < 0.01), and compounds...

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Bibliographic Details
Published inBulletin of the Korean Chemical Society Vol. 35; no. 12; pp. 3489 - 3494
Main Authors Li, Chungang, Sun, Yiping, Wang, Guoping, Tan, Xiangduan
Format Journal Article
LanguageKorean
Published 2014
Subjects
Leukocyte-increasing activity
Leukopenia
rhG-CSF
Dithiolopyrrolone derivatives
Antileukopenia
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Summary:In search of new antileukopenia agents, twenty dithiolopyrrolone derivatives were synthesized and evaluated for their leukocyte-increasing activities in normal mice. Among the synthesized compounds 4-23, compounds 5 and 6 showed significant leukocyte-increasing activity ( p < 0.01), and compounds 4, 9 and 16 had a moderate effect ( p < 0.05). Compound 5 also displayed stronger leukocyte-increasing activity than that of the positive recombinant human granulocyte colony stimulating factor (rhG-CSF). Above all, compound 5 would be a potential antileukopenia agent which deserved further research.
Bibliography:KISTI1.1003/JNL.JAKO201436438765308
ISSN:0253-2964
1229-5949