Neuroendocrine tumors in the Iran Cancer Institute: Predictive Factors of Patient Survival

• Published in: Asian Pacific journal of cancer prevention : APJCP Vol. 15; no. 18; pp. 7835 - 7838
• Main Authors: Sadighi, Sanambar, Roshanaee, Ghodratollah, Vahedi, Saba, Jahanzad, Easa, Mohagheghi, Mohammad Ali, Mousavi-Jarahi, Alireza
• Format: Journal Article
• Language: Korean
• Published: 2014
• Subjects: Neuroendocrine neoplasms; carcinoid tumors; survival; Cox proportional hazard model; chemotherapy
• ISSN: 1513-7368; 2476-762X

Background: Neuroendocrine tumors have widespread and different clinical presentations and prognoses. This study was conducted to assess their survival time and prognostic factors in Iran. Materials and Methods: In a retrospective cohort study, 189 patients diagnosed of having neuroendocrine carcinoma were chosen. The tumor and clinical characteristics of the patients were modeled with a Cox proportional hazard approach. Survival was assessed using Kaplan-Meyer curves. Results: Crude median survival time was 30 months. Women survived longer than men (the median survival time for women was 40 and for men was 24 months). Age (<60 vs >60 years old with hazard ratio (HR) of 2.43, 95% CI 1.3-4.5), primary pathology report (carcinoid vs. others with HR 5.85 cm, 95% CI 2.4-14.3), tumor size cm (for 5-10, HR of 3.1, 95% CI 1.6 and for >10 HR of 8.2, 95% with 95% CI 3.1-21.9), and chemotherapy with single drug (taking vs. not taking with a HR 2.2, 95% CI 1.1-4.8) had significant effects on overall survival of patients. Conclusions: Survival time in patients with neuroendocrine carcinomas is related to demographics, clinical characteristics, tumor histology, and subtype specific treatment.