Compounds from the Aerial Parts of Aceriphyllum rossii and Their Cytotoxic Activity

The purification of the MeOH extracts from the aerial parts of Aceriphyllum rossii Engler (Saxifragaceae) using column chromatography furnished fourteen compounds (1 - 14). The chemical structures of the isolated compounds were determined using mainly nuclear magnetic resonance spectra and mass spec...

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Published inNatural product sciences Vol. 20; no. 3; pp. 146 - 151
Main Authors Tran, Thi Thu Trang, Nguyen, Thi Yen, Tran, Manh Hung, Weon, Kwon-Yeon, Woo, Mi Hee, Min, Byung Sun
Format Journal Article
LanguageKorean
Published 2014
Subjects
Aceriphyllum rossii
Cancer cells
Saxifragaceae
Cytotoxic activity
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Summary:The purification of the MeOH extracts from the aerial parts of Aceriphyllum rossii Engler (Saxifragaceae) using column chromatography furnished fourteen compounds (1 - 14). The chemical structures of the isolated compounds were determined using mainly nuclear magnetic resonance spectra and mass spectrometry. All the isolated compounds were tested for their cytotoxic activity against LH-60, MCF-7 and HeLa cancer cells in vitro using a MTT assay method. Compounds possessing an olean-triterpenoid skeleton entirely exhibit dose dependent cytotoxic activity. These findings partially confirmed the anticancer effect of this medicinal plant, suggesting a further study on the anticancer potential of the triterpenoid structure in compounds from this plant.
Bibliography:KISTI1.1003/JNL.JAKO201430754388365
ISSN:1226-3907